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ADPKD is a multi-systemic disease and as kidney cyst grow and total kidney volume (TKV) increase, patients with ADPKD can experience symptoms including:

  • Pain in the abdomen, flank or lower back
  • Hematuria
  • Hypertension and cardiac abnormalities
  • Nephrolithiasis
  • Cyst rupture and infection
  • Intracranial aneurysms

Cysts may also grow in the liver, pancreas and other organs leading to extra-kidney manifestations.


 Symptoms ADPKD

CNS, central nervous system; LVH, left ventricular hypertrophy.




1. Harris PC, Torres VE. Polycystic Kidney Disease, Autosomal Dominant. 2002 Jan 10 [Updated 2018 Jul 19]. In: Adam MP, Ardinger HH, Pagon RA, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2020. Available from:

2. Luciano RL, Dhal NK. Nephrol Dial Transplant. 2014; 29: 247–254;

3. Torra R. Polycystic Kidney Disease Clinical Presentation. Accessed November 18, 2020.







Last Updated: Mar 3, 2021
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